Differential expression of retinoid receptors in the adult mouse central nervous system

The immunocytochemical distribution of retinoid receptors has been analysed in the mouse adult central nervous system. All retinoic acid receptors (al pha, beta and gamma) and retinoid X receptors (alpha, beta and gamma) were detected and found to exhibit specific patterns of expression in various ar eas of the telencephalon, diencephalon and rhombencephalon. The protein loc alization of several retinoic acid receptors and retinoid X receptors did n ot correlate with the distribution of the corresponding RNA transcripts, as studied by in situ hybridization and RNase protection assays. This suggests that the expression of retinoid receptors could be post-trans criptionally regulated, which may contribute to their specific localization in the adult nervous system. (C) 1999 IBRO. Published by Elsevier Science Ltd.