Background Epidemiologic studies have reported differences in the use of ca
rdiovascular procedures according to the race and sex of the patient. Wheth
er the differences stem from differences in the recommendations of physicia
ns remains uncertain.
Methods We developed a computerized survey instrument to assess physicians'
recommendations for managing chest pain. Actors portrayed patients with pa
rticular characteristics in scripted interviews about their symptoms. A tot
al of 720 physicians at two national meetings of organizations of primary c
are physicians participated in the survey. Each physician viewed a recorded
interview and was given other data about a hypothetical patient. He or she
then made recommendations about that patient's care. We used multivariate
logistic-regression analysis to assess the effects of the race and sex of t
he patients on treatment recommendations, while controlling for the physici
ans' assessment of the probability of coronary artery disease as well as fo
r the age of the patient, the level of coronary risk, the type of chest pai
n, and the results of an exercise stress test.
Results The physicians' mean (+/-SD) estimates of the probability of corona
ry artery disease were tower for women (probability, 64.1+/-19.3 percent, v
s. 69.2+/-18.2 percent for men; P<0.001), younger patients (63.8+/-19.5 per
cent for patients who were 55 years old, vs. 69.5+/-17.9 percent for patien
ts who were 70 years old; P<0.001), and patients with non-anginal pain (58.
3+/-19.0 percent, vs. 64.4+/-18.3 percent for patients with possible angina
and 77.1+/-14.0 percent for those with definite angina; P<0.001). Logistic
-regression analysis indicated that women (odds ratio, 0.60; 95 percent con
fidence interval, 0.4 to 0.9; P=0.02) and blacks (odds ratio, 0.60; 95 perc
ent confidence interval, 0.4 to 0.9; P=0.02) were less likely to be referre
d for cardiac catheterization than men and whites, respectively. Analysis o
f race-sex interactions showed that black women were significantly less lik
ely to be referred for catheterization than white men (odds ratio, 0.4; 95
percent confidence interval, 0.2 to 0.7; P=0.004).
Conclusions Our findings suggest that the race and sex of a patient indepen
dently influence how physicians manage chest pain. (N Engl J Med 1999;340:6
18-26.) (C)1999, Massachusetts Medical Society.