Efficient synthesis of N-4 alkyl derivatives of 2 ',3 '-dideoxycytidine (ddC).

Authors
Dechaux, E Pontikis, R Monneret, C
Citation
E. Dechaux et al., Efficient synthesis of N-4 alkyl derivatives of 2 ',3 '-dideoxycytidine (ddC)., NUCLEOS NUC, 18(1), 1999, pp. 1-4
Citations number
13
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
1
Year of publication
1999
Pages
1 - 4
Database
ISI
SICI code
0732-8311(1999)18:1<1:ESONAD>2.0.ZU;2-K
Abstract
The C-4 triisopropylphenylsulfonyl (TPS) group of the 2',3'-dideoxyuridine derivative 2 is readily displaced in sine by nitrogen nucleophiles forming N-4 substituted ddC in acceptable yields.