Treatment of the sodium salt of compounds 1, 7 or 12 with chloroethyl methy
l ether, 2-chloroethyl toluoylate or 2-(2-chloro ethoxy)ethyl acetate affor
ded the corresponding derivatives 2, 3, 4, 8, 9, 13 and 14. Ammonolysis of
3, 4, 9 and 14 at room temperature gave the corresponding hydroxyalkyl deri
vatives 5, 6, 10, 11, and 15, respectively. Alkylation of 2,4-dithiouracil
gave 2,4-dialkylthio pyrimidine.