Synthesis of new thiolated acyclonucleosides with potential anti-HBV activity

Authors
Zeid, IF Abdel-Rahman, AAH Abdel-Megied, AES El-Etrawy, AASH
Citation
If. Zeid et al., Synthesis of new thiolated acyclonucleosides with potential anti-HBV activity, NUCLEOS NUC, 18(1), 1999, pp. 95-111
Citations number
19
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
1
Year of publication
1999
Pages
95 - 111
Database
ISI
SICI code
0732-8311(1999)18:1<95:SONTAW>2.0.ZU;2-7
Abstract
Treatment of the sodium salt of compounds 1, 7 or 12 with chloroethyl methy l ether, 2-chloroethyl toluoylate or 2-(2-chloro ethoxy)ethyl acetate affor ded the corresponding derivatives 2, 3, 4, 8, 9, 13 and 14. Ammonolysis of 3, 4, 9 and 14 at room temperature gave the corresponding hydroxyalkyl deri vatives 5, 6, 10, 11, and 15, respectively. Alkylation of 2,4-dithiouracil gave 2,4-dialkylthio pyrimidine.