L-myc genotypes in Hong Kong Chinese colorectal carcinoma patients

L-myc genotypes have been correlated with prognosis in different human tumo rs. Its role in colorectal carcinoma (CRC) is still unclear. This study aim ed to assess the L-myc genotypes in 99 Hong Kong Chinese CRC patients by PC R-RFLP techniques. The results obtained were correlated with clinical, hist ological and pathological parameters and genetic alterations. The observed frequency of L-myc genotypes (LL:LS:SS) was 27:46:26. The ratio of S to L a lleles was 0.51:0.49. Distribution of L-myc genotypes and alleles in Hong K ong Chinese CRC was similar to that of healthy Chinese and CRC patients of other ethnic origins. The homozygous SS genotype was significantly associat ed with Dukes' stages C versus B. Other parameters including sex, different iation status and survival, and genetic alterations such as p53 and Ki-ras mutations and Dec LOH had no significant association with L-myc SS genotype .