Synthesis and polymorphism of cyclic ether phospholipids

Citation
G. Forster et al., Synthesis and polymorphism of cyclic ether phospholipids, PHARMAZIE, 54(1), 1999, pp. 31-35
Citations number
10
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMAZIE
ISSN journal
00317144 → ACNP
Volume
54
Issue
1
Year of publication
1999
Pages
31 - 35
Database
ISI
SICI code
0031-7144(199901)54:1<31:SAPOCE>2.0.ZU;2-Z
Abstract
Homologues of (5-alkoxymethyl-1,3-dioxan-5-yl)methyl-2-(trimethylammonio)et hylphosphates were investigated using differential scanning calorimetry and X-ray diffraction. The water saturated compounds show at a decrease in tem perature subsequent transitions from a nonlamellar liquid-crystalline phase to a lamellar gel phase and then at the long chain homologues to a lamella r gelB-phase with interdigitation of the alkyl chains.