Study of local anaesthetics, part 146: Correlation between local anaesthesia, coded structural information, and chromatographic properties for homologous series of alkoxysubstituted esters of phenylcarbamic acid using a neural network
K. Hrobonova et al., Study of local anaesthetics, part 146: Correlation between local anaesthesia, coded structural information, and chromatographic properties for homologous series of alkoxysubstituted esters of phenylcarbamic acid using a neural network, PHARMAZIE, 54(1), 1999, pp. 44-47
RP HPLC capacity factors were used for the characterisation of the lipophil
icity of homologous series of o- and m-alkoxy-substituted pyrolidino-, pipe
ridino-, and N-methylpiperazino esters of phenylcarbamic acid. The mathemat
ical method of a neural network was employed for supplementing of the incom
plete original data matrix and fur smoothing the biological data. The depen
dencies of the number of carbon atoms in the alkoxy side chain (nsp. LC cap
acity factors) on the surface anaesthesia for the homologous series have pa
rabolic character. The surface anaesthetic activity of the o-alkoxy-substit
uted derivatives was higher than that of m-alkoxy-substituted derivatives.
m-Alkoxy-substituted eaters presented maxima of activity at 6 and o-derivat
ives at 7 carbon atoms in the alkoxy side chain.