Study of local anaesthetics, part 146: Correlation between local anaesthesia, coded structural information, and chromatographic properties for homologous series of alkoxysubstituted esters of phenylcarbamic acid using a neural network

RP HPLC capacity factors were used for the characterisation of the lipophil icity of homologous series of o- and m-alkoxy-substituted pyrolidino-, pipe ridino-, and N-methylpiperazino esters of phenylcarbamic acid. The mathemat ical method of a neural network was employed for supplementing of the incom plete original data matrix and fur smoothing the biological data. The depen dencies of the number of carbon atoms in the alkoxy side chain (nsp. LC cap acity factors) on the surface anaesthesia for the homologous series have pa rabolic character. The surface anaesthetic activity of the o-alkoxy-substit uted derivatives was higher than that of m-alkoxy-substituted derivatives. m-Alkoxy-substituted eaters presented maxima of activity at 6 and o-derivat ives at 7 carbon atoms in the alkoxy side chain.