The Strongylocentrotus purpuratus genome contains a single ten-gene Hox com
plex >0.5 megabase in length. This complex was isolated on overlapping bact
erial artificial chromosome and P1 artificial chromosome genomic recombinan
ts by using probes for individual genes and by genomic walking. Echinoderm
Hox genes of Paralog Groups (PG) 1 and 2 are reported. The duster includes
genes representing all paralog groups of vertebrate Hox clusters, except th
at there is a single gene of the PG4-5 types and only three genes of the PG
9-12 types. The echinoderm Hox gene cluster is essentially similar to those
of the bilaterally organized chordates, despite the radically altered pent
ameral body plans of these animals.