Immune regulatory loops determine productive interactions within human T lymphocyte dendritic cell clusters

Authors
Stuhler, G Zobywalski, A Grunebach, F Brossart, P Reichardt, VL Barth, H Stevanovic, S Brugger, W Kanz, L Schlossman, SF
Citation
G. Stuhler et al., Immune regulatory loops determine productive interactions within human T lymphocyte dendritic cell clusters, P NAS US, 96(4), 1999, pp. 1532-1535
Citations number
30
Categorie Soggetti
Multidisciplinary
Journal title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN journal
00278424 → ACNP
Volume
96
Issue
4
Year of publication
1999
Pages
1532 - 1535
Database
ISI
SICI code
0027-8424(19990216)96:4<1532:IRLDPI>2.0.ZU;2-V
Abstract
Help for the induction of cytolytic T lymphocytes is mediated by dendritic cells (DC) that are conditioned by CD40 signaling. We identified tumor necr osis factor family member CD27L/CD70, which is expressed by cytolytic T lym phocytes on interaction with DC to control CD154 (CD40L) up-regulation on C D45RA(+) helper T cells for subsequent DC stimulation. The results show tha t the initiation of a cytolytic Immune response is determined by regulatory circuits, requiring simultaneous activation and differentiation of ail cel ls involved in T lymphocyte-DC cluster formation.