CLONING AND CHROMOSOMAL LOCALIZATION OF MOUSE AQUAPORIN-4 - EXCLUSIONOF A CANDIDATE MUTANT PHENOTYPE, ATAXIA

Authors
TURTZO LC LEE MD LU MQ SMITH BL COPELAND NG GILBERT DJ JENKINS NA AGRE P
Citation
Lc. Turtzo et al., CLONING AND CHROMOSOMAL LOCALIZATION OF MOUSE AQUAPORIN-4 - EXCLUSIONOF A CANDIDATE MUTANT PHENOTYPE, ATAXIA, Genomics, 41(2), 1997, pp. 267-270
Citations number
15
Categorie Soggetti
Genetics & Heredity
Journal title
Genomics → ACNP
ISSN journal
08887543
Volume
41
Issue
2
Year of publication
1997
Pages
267 - 270
Database
ISI
SICI code
0888-7543(1997)41:2<267:CACLOM>2.0.ZU;2-V
Abstract
Aquaporin-4 is a mammalian water channel protein that is predominately expressed in brain, where it is believed to mediate water homeostasis . Here we report the isolation and characterization of the cDNA for mo use Aqp4 and map the gene to the proximal region of mouse chromosome 1 8. This region contains the neurological mutation ataxia, but further analysis reveals that Aqp4 is not responsible for the ataxia phenotype . (C) 1997 Academic Press.