LOCALIZATION OF THE HUMAN ROR1 GENE (NTRKR1) TO CHROMOSOME 1P31-P-32 BY FLUORESCENCE IN-SITU HYBRIDIZATION AND SOMATIC-CELL HYBRID ANALYSIS

Ror1 is an orphan cell surface receptor with strong homology to the ty rosine kinase domain of growth factor receptors, in particular the Trk family. Southern blot analysis of genomic DNA from somatic cell hybri ds revealed that Ror1 is located on chromosome 1. We have mapped the R or1 gene to chromosome 1p12-p32 using PCR on a somatic cell hybrid pan el that subdivides chromosome 1p. We have further localized the gene t o chromosome 1p31-p32 by fluorescence in situ hybridization using a PA C clone that contains the Ror1 gene. (C) 1997 Academic Press.