Accelerated phosphodiester cleavage of bis(p-nitrophenyl)-phosphate by receptors

Authors
Ryu, HW Cho, Y Kim, DY Ko, TS
Citation
Hw. Ryu et al., Accelerated phosphodiester cleavage of bis(p-nitrophenyl)-phosphate by receptors, REACT KIN C, 66(1), 1999, pp. 127-132
Citations number
14
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
REACTION KINETICS AND CATALYSIS LETTERS
ISSN journal
01331736 → ACNP
Volume
66
Issue
1
Year of publication
1999
Pages
127 - 132
Database
ISI
SICI code
0133-1736(199901)66:1<127:APCOBB>2.0.ZU;2-2
Abstract
Phosphodiester cleavage of BNPP can be accelerated by various degradative r eceptors including enzymes. In the hydrolytic cleavage of BNPP, a bell-shap ed receptor concentration-rate profile composed of a positive-catalysis pha se at low receptor concentrations and a negative-catalysis phase at excess receptor concentration was observed. The negative catalysis can be explaine d by nonproductive binding, leading to an increase of the activation energy barrier and a decrease of the reaction rate.