Use of lipopolysaccharide (LPS) as a positive control for the evaluation of immunopotentiating drug candidates in experimental avian colibacillosis models

Citation
Ed. Mcgruder et Gm. Moore, Use of lipopolysaccharide (LPS) as a positive control for the evaluation of immunopotentiating drug candidates in experimental avian colibacillosis models, RES VET SCI, 66(1), 1999, pp. 33-37
Citations number
20
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
RESEARCH IN VETERINARY SCIENCE
ISSN journal
00345288 → ACNP
Volume
66
Issue
1
Year of publication
1999
Pages
33 - 37
Database
ISI
SICI code
0034-5288(199902)66:1<33:UOL(AA>2.0.ZU;2-H
Abstract
The aetiologic agent of avian colibacillosis is Escherichia coli. Colibacil losis is a disease that causes mortality and production performance problem s in chickens which results in economic losses for the poultry industry. It will be increasingly important for scientists to identify novel solutions that can be implemented which will provide poultry producers with a tool to manage this economically important disease. The purpose of this investigat ion was to determine whether lipopolysaccharide (LPS) could be used as a po sitive control to evaluate novel chemistries for immunopotentiator activity in battery or floor-pen avian colibacillosis models in chickens. In the ba ttery study, subcutaneous administration of LPS to one-day-old broiler cock erels caused a significant reduction (P < 0.003) in all parameters of colib acillosis evaluated, i.e. mean air sac lesion scores, per cent air sac lesi ons, E coli re-isolation and per cent mortality. However, in the floor-pen study, subcutaneous administration to one-day-old broiler chicks resulted i n a numerical, but not stastically significant reduction (P < 0.1) in morta lity associated with colibacillosis. These data indicate that LPS can be us ed as a positive control to evaluate the efficacy of immunopotentiator drug candidates in avian colibacillosis models.