How to manage undesirable drug interactions in the treatment of infectiousdiseases?

TABLE OF CONTENTS A) Undesirable combination of two antiinfectious agents with a potential fo r antagonistic effects or cross-resistance a) antibacterial antagonism b) antiviral antagonism and/or cross-resistance between two antiviral agent s c) antiparasite antagonism d) antifungal antagonism B) Undesirable combination of drugs with similar toxicities : gastrointesti nal, hepatic, neurological, renal, hematological, cardiac, and allergic eff ects. C) Undesirable combination of drugs with pharmacokinetic interactions invol ving: 1) digestive absorption, 2) plasma protein binding, 3) metabolic induction or inhibition or cytochrome P450 enzymes, 4) renal excretion.