An efficient synthesis of 6-substituted 2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolines.

Authors
Urban, FJ Breitenbach, R
Citation
Fj. Urban et R. Breitenbach, An efficient synthesis of 6-substituted 2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolines., SYN COMMUN, 29(4), 1999, pp. 645-653
Citations number
7
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
29
Issue
4
Year of publication
1999
Pages
645 - 653
Database
ISI
SICI code
0039-7911(1999)29:4<645:AESO62>2.0.ZU;2-R
Abstract
A synthesis of 6-nitro and 6-amino 2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4 -tetrahydro-isoquinolines using a bis-alkylation process is described. 5-(A minomethyl)-1-(p-methoxybenzyl)-triazole was prepared by a regioselective r oute from 1,2,4-triazole.