Synthesis of 6-substituted-3-hydroxy-4-(1H)-pyridinones: Oxidation-Michaeladdition of 3-hydroxy-4(1H)-pyridinones

Authors
Li, MS Gu, LQ Huang, ZS Xiao, SH Ma, L
Citation
Ms. Li et al., Synthesis of 6-substituted-3-hydroxy-4-(1H)-pyridinones: Oxidation-Michaeladdition of 3-hydroxy-4(1H)-pyridinones, TETRAHEDRON, 55(8), 1999, pp. 2237-2244
Citations number
9
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
55
Issue
8
Year of publication
1999
Pages
2237 - 2244
Database
ISI
SICI code
0040-4020(19990219)55:8<2237:SO6O>2.0.ZU;2-X
Abstract
2-Alkyl-3-hydroxy-4(1H)-pyridinones can be oxidized by silver(I) oxide in a lcoholic solution to give 2-alkoxy-2-alkyl-1,2dihydro-pyridine-3,4-diones, which can subsequently undergo a Michael addition with nucleophiles to give 6-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones. (C) 1999 Elsevier Scien ce Ltd. All rights reserved.