Total synthesis of 2-Arachidonylglycerol (2-Ara-Gl)

Authors
Han, LN Razdan, RK
Citation
Ln. Han et Rk. Razdan, Total synthesis of 2-Arachidonylglycerol (2-Ara-Gl), TETRAHEDR L, 40(9), 1999, pp. 1631-1634
Citations number
10
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
9
Year of publication
1999
Pages
1631 - 1634
Database
ISI
SICI code
0040-4039(19990226)40:9<1631:TSO2(>2.0.ZU;2-3
Abstract
Total synthesis of 2-Arachidonylglycerol (2-Ara-Gl) was accomplished starti ng from arachidonic acid and glycerol. The sequence involves selective prot ection of the primary alcohols of glycerol, esterification, and mild hydrol ysis of the protecting groups. A unique hydrolysis condition was developed to prevent isomerization of the 2-Ara-Gl to the more stable I-monoglyceride . (C) 1999 Elsevier Science Ltd. All rights reserved.