Effect of hepatocyte growth factor on tacrolimus-induced nephrotoxicity inspontaneously hypertensive rats

Citation
S. Takada et al., Effect of hepatocyte growth factor on tacrolimus-induced nephrotoxicity inspontaneously hypertensive rats, TRANSPLAN I, 12(1), 1999, pp. 27-32
Citations number
23
Categorie Soggetti
Surgery
Journal title
TRANSPLANT INTERNATIONAL
ISSN journal
09340874 → ACNP
Volume
12
Issue
1
Year of publication
1999
Pages
27 - 32
Database
ISI
SICI code
0934-0874(1999)12:1<27:EOHGFO>2.0.ZU;2-M
Abstract
Renal toxicity is a serious side effect of therapy with tacrolimus (FK506), an immunosuppressive agent administered to renal transplant recipients. We investigated the effect of hepatocyte growth factor (HGF) on tacrolimus-in duced nephrotoxicity in spontaneously hypertensive rats (SHR). After a righ t nephrectomy, rats received a continuous perfusion of either HGF in a dose of 5 mu g/kg daily (tacrolimus + HGF group) or normal saline (tacrolimus g roup) into the left renal artery at a rate of 1 mu l/h for 7 days after sur gery. Tacrolimus was injected intramuscularly in a dose of 4 mg/kg daily fo r 10 days after surgery. HGF significantly inhibited the tacrolimus-induced increase in the serum creatinine (SCr) level (P < 0.05). HGF also prevente d the tacrolimus-induced loss in body weight. The bromodeoxyuridine (BrdU) index was significantly higher in kidney specimens from the tacrolimus + HG F group. These findings suggest that HGF induces the regeneration of renal tubular cells and suppresses tacrolimus-induced renal toxicity in SHR.