Lower motor neuron disease in the Griffon Briquet Vendeen dog

Two 2-month-old Griffon Briquet Vendeen pups from the same litter were eval uated for progressive weakness and hind limb paresis. The paraparesis progr essed rapidly to extensor paralysis with subsequent involvement of the fore limbs with flexor paralysis. The appendicular muscles of all four limbs bec ame progressively atrophied. Lesions included severe loss of neurons in the ventral horns of the spinal cord, Wallerian degeneration of ventral spinal roots, and peripheral nerve and neurogenic appendicular muscular atrophy. The clinical and morphological findings were consistent with a progressive lower motor neuron disease.