Production of gastroesophageal erosions and ulcers (GEU) in gnotobiotic swine monoinfected with fermentative commensal bacteria and fed high-carbohydrate diet

Erosions and gastroesophageal ulcers (GEU) were produced in the pars esopha gea of young gnotobiotic swine fed a carbohydrate-enriched liquid diet and monoinfected with two different fermentative commensal bacteria, Lactobacil lus and Bacillus sp. In contrast, piglets, fed a similar diet and inoculate d with Gastrospirillum sp. (Helicobacter heilmannii), a helicobacter specie s that colonizes the gastric mucosa, did not develop GEU. Experimental GEU likely develops secondary to epithelial damage mediated by microbial-origin acids whose production is potentiated by high dietary carbohydrate and par ietal cell-origin hydrochloric acid.