Rhino-9J (hr(rh9J)): A new allele at the hairless locus

Citation
Jp. Sundberg et D. Boggess, Rhino-9J (hr(rh9J)): A new allele at the hairless locus, VET PATH, 35(4), 1998, pp. 297-299
Citations number
13
Categorie Soggetti
Veterinary Medicine/Animal Health","Medical Research Diagnosis & Treatment
Journal title
VETERINARY PATHOLOGY
ISSN journal
03009858 → ACNP
Volume
35
Issue
4
Year of publication
1998
Pages
297 - 299
Database
ISI
SICI code
0300-9858(199807)35:4<297:R(ANAA>2.0.ZU;2-F
Abstract
A spontaneous mutation arose in the MRL/MpJ-Fas(lpr)/Fas(lpr) colony in whi ch mice lost hair after completion of the first hair cycle. Hair loss was p rogressive from head to tail. As these mice aged, they developed wrinkled s kin and long curved nails. Histologically, affected skin developed comedone s (pilary cysts), deep dermal cysts, and dermal foreign body granulomas ass ociated with rupture of the follicles. The alopecic epidermis was acanthoti c. The mutation was autosomal recessive. Crosses with RHJ/Le + /hr(rhJ) (rh ino-J) mutant mice yielded affected offspring with the same phenotype, veri fying the presence of a new allele of rhino, a mutation at the hairless (hr ) locus on mouse chromosome 14.