Jd. Siebert et al., Relative frequencies and sites of presentation of lymphoid neoplasms in a community hospital according to the revised European-American classification, AM J CLIN P, 111(3), 1999, pp. 379-386
Citations number
31
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Relative frequencies for common subtypes in the revised European-American c
lassification of lymphoid neoplasms (REAL classification) have been reporte
d. We determined the relative frequencies and sites of presentation of REAL
subtypes at a 700-bed community hospital in central Illinois. A database w
as used to identify and prospectively catalogue all newly diagnosed lymphoi
d neoplasms from July 1, 1995 to March 1, 1998. The approach to diagnosis a
nd subtyping incorporated morphologic features, immunophenotype, and clinic
al findings according to criteria proposed in the REAL classification. Of 3
47 lymphoid neoplasms diagnosed, 319 were subtyped in the REAL classificati
on Of these, 261 were B-cell neoplasms, 21 were T-cell neoplasms, and 37 we
re Hodgkin disease variants. Chronic lymphocytic leukemia/small lymphocytic
lymphoma/prolymphocytic leukemia, diffuse large cell, and follicle center
neoplasms were the most common B-cell subtypes. Large granular lymphocyte l
eukemia was the most common T-cell neoplasm. Nodular sclerosis was the most
common Hodgkin disease variant. The relative frequencies in a US community
hospital setting are similar to those reported in other studies. Differenc
es are attributable to patient selection criteria, study group geographic l
ocation and racial composition, and/or referral patterns. Diverse REAL clas
sification subtypes may be expected in US community hospitals.