Vitamin E (alpha-tocopherol) does plot inhibit platelet stimulation by oxidized low density lipoprotein in vitro

Platelet-rich plasma were treated with increasing concentrations of vitamin E (alpha-tocopherol). Washed platelets were exposed to oxidized low densit y lipoprotein (LDL) and examined by aggregometry and electron microscopy, T he treatment of washed platelets by oxidized LDL induced morphological sign s of activation like pseudopodia formation and an increase in light transmi ssion, alpha-Tocopherol In a range of 0.001-1.0 mmol had no inhibiting infl uences on platelet activation by oxidized LDL. These results indicate that the free radical scavenger vitamin E cannot directly inhibit platelet activ ation by oxidized LDL, it may be supposed that platelet activation by oxidi zed LDL does not occur in a radical-dependent mechanism. Am. J. Hematol. 60 :242-244, 1999. (C) 1999 Wiley-Liss, Inc.