Y chromosomal DNA polymorphisms were used to investigate Pleistocene male m
igrations to the American continent. In a worldwide sample of 306 men, we o
btained 32 haplotypes constructed with the variation found in 30 distinct p
olymorphic sites. The major Y haplotype present in most Native Americans wa
s traced back to recent ancestors common with Siberians, namely, the Kets a
nd Altaians from the Yenissey River Basin and Altai Mountains, respectively
. Going further back, the next common ancestor gave rise also to Caucasoid
Y chromosomes, probably from the central Eurasian region. This study, there
fore, suggests a predominantly central Siberian origin for Native American
paternal lineages for those who could have migrated to the Americas during
the Upper Pleistocene.