Penetration of meropenem in lung, bronchial mucosa, and pleural tissues

Authors
Byl, B Jacobs, F Roucloux, I de Franquen, P Cappello, M Thys, JP
Citation
B. Byl et al., Penetration of meropenem in lung, bronchial mucosa, and pleural tissues, ANTIM AG CH, 43(3), 1999, pp. 681-682
Citations number
14
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
3
Year of publication
1999
Pages
681 - 682
Database
ISI
SICI code
0066-4804(199903)43:3<681:POMILB>2.0.ZU;2-1
Abstract
Lung, bronchial mucosa, and pleural tissue samples were obtained from 14 pa tients undergoing lung surgery 1 to 5 h after administration of 1 g of mero penem. The mean (range) peak concentrations of meropenem were 3.9 (0.2 to 8 .2), 6.6 (3.0 to 13.3), and 2.8 (0.6 to 7.8) mg/kg of tissue, respectively, exceeding the MICs at which 90% of isolates are inhibited for most respira tory pathogens.