Declining concentrations of dihydroartemisinin in plasma during 5-day oraltreatment with artesunate for falciparum malaria

Authors
Khanh, NX de Vries, PJ Ha, LD van Boxtel, CJ Koopmans, R Kager, PA
Citation
Nx. Khanh et al., Declining concentrations of dihydroartemisinin in plasma during 5-day oraltreatment with artesunate for falciparum malaria, ANTIM AG CH, 43(3), 1999, pp. 690-692
Citations number
15
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
3
Year of publication
1999
Pages
690 - 692
Database
ISI
SICI code
0066-4804(199903)43:3<690:DCODIP>2.0.ZU;2-L
Abstract
Six patients with uncomplicated falciparum malaria received artesunate for 5 days. Plasma concentrations of artesunate and dihydroartemisinin were det ermined by high-performance liquid chromatography with electrochemical dete ction. The concentrations of dibydroartemisinin in plasma 2 h after a dose showed a time-dependent decline. Concentrations of artesunate in plasma esp ecially after the last dose, were very low. Despite this, all patients resp onded. with a fast recovery.