Lactic acid polymers as biodegradable carriers of fluoroquinolones: An in vitro study

Authors
Kanellakopoulou, K Kolia, M Anastassiadis, A Korakis, T Giamarellos-Bourboulis, EJ Andreopoulos, A Dounis, E Giamarellou, H
Citation
K. Kanellakopoulou et al., Lactic acid polymers as biodegradable carriers of fluoroquinolones: An in vitro study, ANTIM AG CH, 43(3), 1999, pp. 714-716
Citations number
15
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
3
Year of publication
1999
Pages
714 - 716
Database
ISI
SICI code
0066-4804(199903)43:3<714:LAPABC>2.0.ZU;2-I
Abstract
A biodegradable polymer of DL-dilactide that facilitates release of ciprofl oxacin or pefloxacin at levels exceeding MICs for the causative microorgani sms of chronic osteomyelitis is described. Duration and peak of release wer e found to depend on the molecular weight of the polymer. Its characteristi cs make it promising for treating chronic bone infections.