Changes in antioxidant enzyme activities and lipid peroxidation related tobromoethylamine-induced renal cytotoxicity

Background. The effect of bromoethylamine (BEA) administration on lipid per oxidation and on the activities of antioxidant enzymes was studied. Methods. Adult rats received BEA at 1.2 mmol/kg, a dose that produces renal papillary necrosis, Lipid peroxidation assessed by maximal rate in MDA for mation, the activities of catalase, superoxide dismutase (SOD) and glutathi one peroxidase (GSH-Px), and the levels of non-protein sulfhydryls (NPSH) w ere measured in renal cortex and papilla of control and BEA-treated animals . Results. After BEA treatment, an increment in lipid peroxidation in papilla and cortex was found after 1.5 and 24 hours of treatment. Catalase activit y decreased in both regions, but earlier in cortex. Conclusion. These data suggest some role of oxidative stress in the mechani sm of BEA-induced papillary necrosis. (C) 1999 IMSS. Published by Elsevier Science Inc.