J. Wu et al., Evidence of Trolox and some gallates as synergistic protectors of erythrocytes against peroxyl radicals, BIOC CELL B, 76(4), 1998, pp. 661-664
Citations number
9
Categorie Soggetti
Cell & Developmental Biology
Journal title
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
The peroxidation of human erythrocytes induced by peroxyl radical initiator
and its inhibition by several gallate esters (e.g., propyl, methyl, ethyl)
and Trolox (a more polar analogue of vitamin E) have been studied. The ant
ioxidant activity was determined on erythrocytes against hemolysis generate
d by a thermal activator, 2,2'-azobis-(2-amidinopropane)dihydrogenchloride.
It was found that propyl gallate and its two analogues were more effective
than Trolox in preventing cell lysis. However, the combination of gallate
esters and Trolox produced a protective effect exceeding the arithmetic sum
of their individual contributions. These perceived synergisms occur at mor
e than one level of Trolox at a given level of a gallate ester.