Carbohydroxamido-oxazolidines: Antibacterial agents that target lipid A biosynthesis

Authors
Chen, MH Steiner, MG de Laszlo, SE Patchett, AA Anderson, MS Hyland, SA Onishi, HR Silver, LL Raetz, CRH
Citation
Mh. Chen et al., Carbohydroxamido-oxazolidines: Antibacterial agents that target lipid A biosynthesis, BIOORG MED, 9(3), 1999, pp. 313-318
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
3
Year of publication
1999
Pages
313 - 318
Database
ISI
SICI code
0960-894X(19990208)9:3<313:CAATTL>2.0.ZU;2-#
Abstract
A series of carbohydroxamido-oxazolidine inhibitors of UDP-3-O-[R-3-hydroxy myristoyl]-GlcNAc deacetylase, the enzyme responsible for the second step i n lipid A biosynthesis, was identified. The most potent analog L-161,240 sh owed an IC50 = 30 nM in the DEACET assay and displayed an MIC of 1-3 mu g/m L against wild-type E. coli. (C) 1999 Elsevier Science Ltd. All rights rese rved.