Substituted furans as inhibitors of the PDE4 enzyme

Authors
Perrier, H Bayly, C Laliberte, F Huang, Z Rasori, R Robichaud, A Girard, Y Macdonald, D
Citation
H. Perrier et al., Substituted furans as inhibitors of the PDE4 enzyme, BIOORG MED, 9(3), 1999, pp. 323-326
Citations number
8
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
3
Year of publication
1999
Pages
323 - 326
Database
ISI
SICI code
0960-894X(19990208)9:3<323:SFAIOT>2.0.ZU;2-G
Abstract
The synthesis and in vitro activity of a series of substituted furans as a novel structural class of PDE4 inhibitors is described. Comparison of emeti c threshold with known PDE4 inhibitors is presented. (C) 1999 Elsevier Scie nce Ltd. All rights reserved.