Synthesis and biological evaluation of 1 alpha,24-dihydroxy-25-nitrovitamin D-3

Authors
Oshida, J Okamoto, M Ishizuka, S Azuma, S
Citation
J. Oshida et al., Synthesis and biological evaluation of 1 alpha,24-dihydroxy-25-nitrovitamin D-3, BIOORG MED, 9(3), 1999, pp. 381-384
Citations number
24
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
3
Year of publication
1999
Pages
381 - 384
Database
ISI
SICI code
0960-894X(19990208)9:3<381:SABEO1>2.0.ZU;2-#
Abstract
1 alpha,24(R)-Dihydroxy-25-nitrovitamin D-3 1 and 1 alpha,24(S)-dihydroxy-2 5-nitrovitamin D-3 2 were synthesized using the palladium-catalyzed; alkyla tive enyne cyclization reaction. Their biological properties were studied b ased on VDR binding affinity and HL-60 cell differentiation activity. (C) 1 999 Elsevier Science Ltd. All rights reserved.