Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones

Authors
Jarvest, RL Pinto, IL Ashman, SM Dabrowski, CE Fernandez, AV Jennings, LJ Lavery, P Tew, DG
Citation
Rl. Jarvest et al., Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones, BIOORG MED, 9(3), 1999, pp. 443-448
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
3
Year of publication
1999
Pages
443 - 448
Database
ISI
SICI code
0960-894X(19990208)9:3<443:IOHPAA>2.0.ZU;2-Z
Abstract
Cinnamyl derivatives of thieno[2,3-d]oxazinones are mechanism-based inhibit ors of the HSV-2, VZV and CMV herpes proteases which demonstrate nanomolar potency. Compounds 5 and 28 inhibit protease processing in HSV-2 infected c ells with a selectivity index of at least 30. (C) 1999 Elsevier Science Ltd . Ail rights reserved.