Leucine-phenylalanine dipeptide-based N-mesyloxysuccinimides: Synthesis ofall four stereoisomers and their assay against serine proteases

Authors
Abell, AD Oldham, MD
Citation
Ad. Abell et Md. Oldham, Leucine-phenylalanine dipeptide-based N-mesyloxysuccinimides: Synthesis ofall four stereoisomers and their assay against serine proteases, BIOORG MED, 9(3), 1999, pp. 497-500
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
3
Year of publication
1999
Pages
497 - 500
Database
ISI
SICI code
0960-894X(19990208)9:3<497:LDNSO>2.0.ZU;2-C
Abstract
The four stereoisomers of 3-(N-acetylleucylamino)-3-benzyl-1-[(methylsulfon yl)oxy]succinimide have been prepared and shown to inhibit alpha-chymotryps in and human neutrophil elastase. The structural and stereochemical feature s that affect the potency and selectivity of inhibition are discussed. (C) 1999 Elsevier Science Ltd. All rights reserved.