Effects of long term feeding of raw soya bean flour on virus-induced pancreatic carcinogenesis in guinea fowl

The effects of a diet enriched with 25% raw soya bean flour (RSF) on the pa ncreas and on the avian retrovirus Pts 56-induced pancreatic carcinogenesis in guinea fowl were studied. It has been shown that prolonged RSF feeding of new-hatched virus-infected and uninfected guinea fowl-poults induced enl argement of the pancreas, which was less pronounced when administration of the RSF supplemented diet started at the age of 75 days. Time-dependent mul tifocal inter- and intralobular hyperplasia of pleomorphic ducts lined by m ucin-producing epithelium in the exocrine pancreas of virus-infected guinea fowls fed a RSF supplemented diet was regularly observed. Enlargement of v irus induced ductular neoplasms has been shown only after simultaneous RSF and virus administration. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.