T. Kirev et al., Effects of long term feeding of raw soya bean flour on virus-induced pancreatic carcinogenesis in guinea fowl, CANCER LETT, 135(2), 1999, pp. 195-202
The effects of a diet enriched with 25% raw soya bean flour (RSF) on the pa
ncreas and on the avian retrovirus Pts 56-induced pancreatic carcinogenesis
in guinea fowl were studied. It has been shown that prolonged RSF feeding
of new-hatched virus-infected and uninfected guinea fowl-poults induced enl
argement of the pancreas, which was less pronounced when administration of
the RSF supplemented diet started at the age of 75 days. Time-dependent mul
tifocal inter- and intralobular hyperplasia of pleomorphic ducts lined by m
ucin-producing epithelium in the exocrine pancreas of virus-infected guinea
fowls fed a RSF supplemented diet was regularly observed. Enlargement of v
irus induced ductular neoplasms has been shown only after simultaneous RSF
and virus administration. (C) 1999 Elsevier Science Ireland Ltd. All rights
reserved.