Synthesis of trimethylhydroquinone derivatives as anti-allergic agents with anti-oxidative actions

A novel series of trimethylhydroquinone derivatives was synthesized and eva luated for their anti-lipid peroxidation activity in rat liver microsomes, inhibition of rat basophilic leukemia-1 (RBL-1) cell 5-lipoxygenase and 48 h homologous passive cutaneous anaphylaxis (PCA) activity in rats. 4-[4-[4- (Diphenylmethyl)-1-piperazinyl]-butoxy]-2,3,6-trimethylphenol (9c) exhibite d the ability to inhibit Fe3+-ADP induced NADPH dependent lipid peroxidatio n (IC50 = 5.3 x 10(-7) M), 5-lipoxygenase ((IC50 =3.5 x 10(-7) M) and PCA r eaction (57% inhibition at 100 mg/kg p.o.).