15-Deoxy-16-(m-tolyl)-17,18,19,20-tetranorisocarbacyclin: a simple TIC derivative with potent anti-apoptotic activity for neuronal cells

Authors
Suzuki, M Kato, K Watanabe, Y Satoh, T Matsumura, K Watanabe, Y Noyori, R
Citation
M. Suzuki et al., 15-Deoxy-16-(m-tolyl)-17,18,19,20-tetranorisocarbacyclin: a simple TIC derivative with potent anti-apoptotic activity for neuronal cells, CHEM COMMUN, (4), 1999, pp. 307-308
Citations number
22
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
4
Year of publication
1999
Pages
307 - 308
Database
ISI
SICI code
1359-7345(19990221):4<307:1ASTD>2.0.ZU;2-S
Abstract
Biologically remarkable 15-deoxy-TIC has been realised by the removal of th e C(15) chiral centre in 15R-TIC, a stable ligand for a CNS-type prostacycl in receptor (IP2); this deoxy derivative exhibits ten-fold higher affinity and selectivity than 15R-TIC for the IP2 receptor in correlation with the a nti-apoptotic activity for neuronal cells.