A new and enantioselective indolizidine synthesis by meso-epoxide alpha-deprotonation-transannular N-C insertion

Authors
Hodgson, DM Robinson, LA
Citation
Dm. Hodgson et La. Robinson, A new and enantioselective indolizidine synthesis by meso-epoxide alpha-deprotonation-transannular N-C insertion, CHEM COMMUN, (4), 1999, pp. 309-310
Citations number
6
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
4
Year of publication
1999
Pages
309 - 310
Database
ISI
SICI code
1359-7345(19990221):4<309:ANAEIS>2.0.ZU;2-S
Abstract
Enantioselective alpha-deprotonation-rearrangement of N-Boc hexahydroazonin e oxide 10 using organolithiums in the presence of (-)-sparteine 3 gives th e ester 12 in up to 89% ee.