Enantiomer separation of fungicidal triazolyl alcohols by normal phase HPLC on polysaccharide-based chiral stationary phases

Three fungicidal triazolyl alcohols (triadimenol, hexaconazole, and cis/tra ns-1-4-chlorophenyl-2-1H-1,2,4-triazol-1-yl-cycloheptanol) were completely separated into enantiomers by chiral HPLC using polysaccharide-based chiral stationary phases. A better separation was achieved on cellulose and amylo se carbamate phases compared with a cellulose ester phase. Peak shapes were almost symmetrical except for two cases, where tailing of the first eluted enantiomer and unusual symmetric peak broadening were observed. The effect of eluents on enantioseparation was also investigated. Chirality 11:195-20 0, 1999. (C) 1999 Wiley-Liss, Inc.