Objective: The aim of this study was to assess the feasibility and outcome
of 300 laparoscopic colorectal procedures performed within 5 years for both
benign and malignant disorders. The specific purpose was to identify the i
mpact of the learning curve on reducing morbidity and on improving the outc
ome of laparoscopic colorectal surgery. Patients and Methods: All cases wer
e divided into 3 groups: the first 100, the second 100 and the third 100 pr
ocedures were analyzed. Statistical analysis was performed by Student's t t
est and chi(2) test. Results: The laparoscopic procedure had to be converte
d to open surgery in 22 cases (mean conversion rate 7.3%). Thus, a total of
278 procedures could be performed laparoscopically. The mean major complic
ation rate was 8.6%, minor complications occurred in 9.7%. The overall morb
idity rate was 18.3%. In 44 cases, laparoscopic resections were performed f
or the cure of colorectal malignancy. The mean lymph node harvest was 12.8
nodes, no port-site recurrence was documented at a mean follow-up of 22 mon
ths. Analyzing our 5-year experience, the incidence of conversion showed a
decline from 8.0% (1st and 2nd 100) to 6.0% in the last 100 procedures (p >
0.05). The major complication rate was significantly decreased from 15 to
6.0% (Ist vs. 2nd 100) and was 5.0% in the 3rd group. The minor complicatio
n rate, overall morbidity rate and laparotomy rate have also been reduced (
p > 0.05). The duration of surgery was shortened from 251.4 to 213.5 min (I
st vs. 2nd 100, p < 0.05) and was 196.9 min in the last 100 procedures. Pos
toperative hospital stay was decreased from 16.3 to 14.3 days (Ist 100 vs.
2nd 100, p > 0.05) and could be shortened to 11.2 days (2nd vs. 3rd 100, p
< 0.05). Conclusion: With increasing experience, laparoscopic colorectal su
rgery can be performed with reduced morbidity and improved outcome. To eval
uate the role of laparoscopic colorectal procedures, particularly for the c
ure of malignancy, prospective randomized trials are necessary.