Composite paraganglioma-ganglioneuroma of the urinary bladder: A clinicopathologic, immunohistochemical, and ultrastructural study of a case and review of the literature

Urinary bladder paragangliomas are rare. An 81-yr-old woman was admitted be cause of whole-stream painless hematuria. Investigations revealed a peduncu lated bladder tumor. Pathological examination showed a biphasic tumor, comp osite paraganglioma-ganglioneuroma. The two separate components were docume nted by both immunohistochemical and ultrastructural studies. A review of t he English literature on urinary bladder paragangliomas showed that the pre sent case is the first case with this unique feature documented in detail, and the patient is the oldest one being reported.