Recurrence and survival analyses of 1,115 cervical cancer patients treatedwith radical hysterectomy

Many clinicopathological factors of cervical cancer are still controversial in their prognostic significance. The case records of 1,115 patients who r eceived radical hysterectomy at the Veterans General Hospital, Taipei, from 1980 to 1989 were collected to evaluate prognosis-related factors by univa riate and multivariate analyses. The pathology was reviewed retrospectively by one pathologist. Ten parameters known to be prognostic in the literatur e were included for analysis. Univariate analysis showed that patients with all these factors had higher recurrence rates. However, when the effects o f parametrial invasion, progressive stage and stromal invasion were weighed against the presence of lymph node metastasis, their influence on recurren ce became unimportant. Nevertheless, these factors still influenced prognos is when there was no lymph node metastasis. Multivariate analysis of both r ecurrence and survival time in the patients with squamous cell carcinoma sh ared a consensus that pelvic lymph node metastasis and deep stromal invasio n were significant risk factors. We conclude that these simplified and cons istent results obtained by multivariate analysis provide a basis for subcla ssification of patients to predict prognosis and change therapy.