Stereoselective synthesis of methylene phosphonate analogues of thymidine 3 '-phosphate and 2 '-deoxyuridine 3 '-phosphate via intramolecular N-glycosylation reaction of thioglycosides

Authors
Yokomatsu, T Shimizu, T Sada, T Shibuya, S
Citation
T. Yokomatsu et al., Stereoselective synthesis of methylene phosphonate analogues of thymidine 3 '-phosphate and 2 '-deoxyuridine 3 '-phosphate via intramolecular N-glycosylation reaction of thioglycosides, HETEROCYCLE, 50(1), 1999, pp. 21-25
Citations number
26
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
50
Issue
1
Year of publication
1999
Pages
21 - 25
Database
ISI
SICI code
0385-5414(19990101)50:1<21:SSOMPA>2.0.ZU;2-C
Abstract
Methylene phosphonate analogues of thymidine 3'-phosphate and 2'-deoxyuridi ne 3'-phosphate were prepared in a stereocontrolled manner through intramol ecular N-glycosylation of phenyl 2,3-dideoxy-3-diethylphosphonomethyl-5-O-( 2-pyrimidinyl)-1-thioglycosides, followed by acid hydrolysis.