4-dimethylaminomethylene-2-pyrazinyl-5(4H)-oxazolone as a synthon for the synthesis of various pyrazoles and fused pyrimidines

Authors
Kepe, V Kozjan, V Polanc, S Kocevar, M
Citation
V. Kepe et al., 4-dimethylaminomethylene-2-pyrazinyl-5(4H)-oxazolone as a synthon for the synthesis of various pyrazoles and fused pyrimidines, HETEROCYCLE, 50(1), 1999, pp. 315-322
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
50
Issue
1
Year of publication
1999
Pages
315 - 322
Database
ISI
SICI code
0385-5414(19990101)50:1<315:4AASFT>2.0.ZU;2-D
Abstract
4-Dimethylaminomethylene-2-pyrazinyl-5(4H)-oxazolone (2) has been synthesiz ed and transformed into various 1,4-disubstituted 1,2-dihydro-5H-pyrazol-5- ones (6) and fused pyrimidinones (8) by the reaction with selected hydrazin es (5) and aminoheterocycles (7). Products (6) and (8) have also been prepa red from methyl 3-dimethylamino-2-(pyrazinylcarbonylamino)propenoate (3) an d nitrogen-containing nucleophiles (5) or (7).