A bright yellow aaptamine, which possesses a never 1H-benzo[d, e][1,6]napht
hyridine skeleton was isolated as a protonic salt from the Okinawan sea spo
nge Aaptos aaptos. Also related compounds, demethylaaptamine and demethylox
yaaptamine were isolated from same origin. We summarize here eight total sy
ntheses containing one formal synthesis of aaptamine and related compounds.