Synthesis of unnatural enantiomer of nectrisine and its biological activity

Authors
Kogoshi, N Takatsuki, A Kim, YJ Kitahara, T
Citation
N. Kogoshi et al., Synthesis of unnatural enantiomer of nectrisine and its biological activity, HETEROCYCLE, 49, 1998, pp. 63-66
Citations number
26
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
49
Year of publication
1998
Pages
63 - 66
Database
ISI
SICI code
0385-5414(199812)49:<63:SOUEON>2.0.ZU;2-0
Abstract
ent-Nectrisine (2), the unnatural enantiomer of nectrisine (1), a potent al pha-glucosidase inhibitor, was synthesized from D-glucose derivative. Biolo gical assay showed that 2 had no significant bioactivity.