Synthesis of acetylcholinesterase inhibitors on the basis of 9-isothiocyanato-1,2,3,4-tetrahydroacridine: 2-[1,2,3,4-tetrahydroacridin-9-yl)imino]-3-substituted 1,3-thiazolidin-4-ones

The synthesis of 2-[(1,2,3,4-tetrahydroacridin-9-yl)imino]-3-substituted 1, 3-thiazolidin-4-ones (5a-e) via cyclization of N-(1,2,3,4-tetrahydroacridin -9-yl)-S-methoxycarbonylmethyl-N'-substituted isothiourea hydrobromides was elaborated. As a synthon, 9-isothiocyanato-1,2,3,4-tetrahydroacridine, an analogue of tacrine, was used. The reaction represents a simple way for the preparation of new cholinergic compounds.