HINDERED ROTATION CONGENERS OF MAZAPERTINE - HIGH-AFFINITY LIGANDS FOR THE 5-HT1A RECEPTOR

Authors
BAXTER EW REITZ AB
Citation
Ew. Baxter et Ab. Reitz, HINDERED ROTATION CONGENERS OF MAZAPERTINE - HIGH-AFFINITY LIGANDS FOR THE 5-HT1A RECEPTOR, Bioorganic & medicinal chemistry letters, 7(7), 1997, pp. 763-768
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
7
Year of publication
1997
Pages
763 - 768
Database
ISI
SICI code
0960-894X(1997)7:7<763:HRCOM->2.0.ZU;2-K
Abstract
Hindered rotation analogs of the antipsychotic mazapertine (1) were pr epared. These compounds exhibited high affinity for the 5-HT1A recepto r, but not for other serotonin or dopamine receptors. The related beta -carboline structures were also synthesized and were found to be poten t 5-HT1A ligands. (C) 1997 Elsevier Science Ltd.