ON THE MECHANISM OF ACTION OF GTP-TRANSFORMING ENZYMES

Authors
DUFTON MJ GIBSON CL PITT AR ATHMANI S SUCKLING CJ
Citation
Mj. Dufton et al., ON THE MECHANISM OF ACTION OF GTP-TRANSFORMING ENZYMES, Bioorganic & medicinal chemistry letters, 7(7), 1997, pp. 779-784
Citations number
36
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
7
Year of publication
1997
Pages
779 - 784
Database
ISI
SICI code
0960-894X(1997)7:7<779:OTMOAO>2.0.ZU;2-#
Abstract
Mechanisms for the ring conversion of GTP into cofactor precursors by GTP cyclohydrolases and molybdopterin synthase are proposed and discus sed in the context of the crystal structure of the GTP cyclohydrolase I-2'-deoxy-GTP complex. The mechanisms suggest that common features of acid-base catalysis may underly the reactions catalysed in all three cases. (C) 1997 Elsevier Science Ltd.