Aqueous phosphoester bond cleavage of dimethyl phosphate by Cp2MoCl2: First reported case of hydrolytic cleavage on an unactivated phosphate diester by an organometallic complex

Authors
Kuo, LY Barnes, LA
Citation
Ly. Kuo et La. Barnes, Aqueous phosphoester bond cleavage of dimethyl phosphate by Cp2MoCl2: First reported case of hydrolytic cleavage on an unactivated phosphate diester by an organometallic complex, INORG CHEM, 38(4), 1999, pp. 814-817
Citations number
32
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
INORGANIC CHEMISTRY
ISSN journal
00201669 → ACNP
Volume
38
Issue
4
Year of publication
1999
Pages
814 - 817
Database
ISI
SICI code
0020-1669(19990222)38:4<814:APBCOD>2.0.ZU;2-E
Abstract
The organometallic compound bis(eta(5)-cyclopentadienyl) molybdenum(IV) dic hloride (Cp2MoCl2, Cp = beta(5)-C5H5) promotes the phosphotester bond cleav age of dimethyl phosphate with rate accelerations of 10(4) at pH 4.0. NMR s pectral evidence suggests this phosphoester bond cleavage proceeds through a hydrolytic pathway where the aquated Cp2MoCl2 binds to the phosphate dies ter and then carries out an intramolecular attack with either a Cp2Mo-bound water or hydroxide. This is the first reported case of an organometallic c omplex that hydrolyzes an unactivated phosphate diester.